Small GTPase / G-Protein Signaling

G proteins are important regulators of various cellular processes including motility, metabolism, and transcription. They are involved in mediating extracellular signals that trigger a cascade of intracellular responses via a series of membrane-bound receptors.

Key to the regulation of the G protein signaling cascade is the involvement of cyclic AMP (cAMP). One of its key functions is to activate Guanine Exchange Factors (GEF), which in turn play a role in the activation of G proteins.

Small GTPases serve to regulate a variety of cell signaling pathways and are therefore involved in a wide range of cell functions, processes and morphology.