AAV-6 Packaging System

AAV-6 Packaging System
  • pHelper plasmid contains required E2A, E4, and VA RNA adenoviral genes; eliminates the need for a helper adenovirus
  • Packaging System contains packaging plasmids and GFP control vector; co-transfect with separate AAV expression vector containing your gene of interest

 

Frequently Asked Questions about AAV Expression and Packaging

General FAQs about using AAV

General FAQs about Viral Gene Delivery

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AAV-6 Helper Free Packaging System
Catalog Number
VPK-406
Size
1 kit
Detection
N/A
Manual/Data Sheet Download
SDS Download
Map Download
Sequence Download
Price
$860.00
Product Details

The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

Viral Gene Delivery using the AAV Helper Free System.

Recent Product Citations
  1. Hartweger, H. et al. (2023). Gene Editing of Primary Rhesus Macaque B Cells. J Vis Exp. doi: 10.3791/64858.
  2. Wen, W. et al. (2021). Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion. Genome Biol. 22(1):236. doi: 10.1186/s13059-021-02462-4.
  3. Lam, A.J. et al. (2021). Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity. Cell Rep. 36(5):109494. doi: 10.1016/j.celrep.2021.109494.
  4. Fu, Y.W. et al. (2021). Dynamics and competition of CRISPR-Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing. Nucleic Acids Res. doi: 10.1093/nar/gkaa1251.
  5. Bougioukli, S. et al. (2020). Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. doi: 10.1038/s41434-020-0182-4.