UV Induced DNA Damage Assays

DNA may be damaged by ultraviolet light resulting in the formation of two structures: cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). The result is a mutation of C to T and CC to TT, which are the most prevalent mutations in p53 found in human and mouse skin cancers.

We offer assays to quantify either CPD or 6-4PP in three formats:

• ELISA kits for use with intact cells
• ELISA kits for DNA isolated from cells or tissues
• Immunofluorescence staining kit

If you are interested in studying both damage structures, consider our CPD and 6-4PP ELISA Combo Kit for use on isolated DNA.