Assay Type | Definition | Cell Types | Pore Size | Insert Coating | Formats |
Chemotaxis | Migration of cells toward a chemoattractant (chemical signal) in the cell's surrounding environment |
Leukocytes Neutrophils |
3 µm | None |
24-Well 96-Well |
Lymphocytes Macrophages Monocytes |
5 µm | None |
24-Well 96-Well |
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Endothelial Cells Epithelial Cells Fibroblasts Tumor Cells |
8 µm | None |
24-Well 96-Well |
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Astrocytes Slow-moving Cells |
12 µm | None | 24-Well | ||
Haptotaxis | Migration of cells along a gradient of cellular adhesion sites or extracellular matrix-bound chemoattractants |
Endothelial Cells Epithelial Cells Fibroblasts |
8 µm | Collagen I (bottom) | 24-Well |
Fibronectin (bottom) | 24-Well | ||||
Transmigration | Migration of cells through the vascular endothelium toward a chemoattractant | Leukocytes | 3 µm | None | 24-Well |
Tumor Cells | 8 µm | None | 24-Well | ||
Invasion | Movement of cells through the 3D extracellular matrix into neighboring tissues; includes ECM degradation and proteolysis |
Endothelial Cells Epithelial Cells Fibroblasts Tumor Cells |
8 µm | ECM Matrix (top) |
24-Well 96-Well |
Collagen I (top) |
24-Well 96-Well |
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Laminin I (top) |
24-Well 96-Well |